By default EntityFramework.SQLite will not work with x64 platform. Here is the tweak which helps you to target your ASP.NET 5 application for x64 platform.

• Find the package install location. This could be %USERPROFILE%.dnx\packages\Microsoft.Data.Sqlite(version)\ - Since I am using beta 8, it is 1.0.0-beta8.

• Create following two folders inside the package location.

• %USERPROFILE%.dnx\packages\Microsoft.Data.Sqlite\1.0.0-beta8\runtimes\win\native\x64

• %USERPROFILE%.dnx\packages\Microsoft.Data.Sqlite\1.0.0-beta8\runtimes\win-x64\native

• Download the System.Data.SQLite Core from nuget.org - You can download it here
• Extract the nuget package - You can use any un zip tool for this purpose.
• Copy the SQLite.Interop.dll from build\net451\x64\ folder, paste to the new folders created in step 2.
• Rename the SQLite.Interop.dll files to sqlite3.dll.

Now you can run the ASP.NET 5 web apps with sqlite targetting x64 platform

Happy Programming